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KMID : 0861019990140010131
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Korea Journal of Herbology
1999 Volume.14 No. 1 p.131 ~ p.140
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Neuroprotective Effects of Daeseungkitang on the Brain Ischemia induced by Four - Vessel Occlusion in Rats
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Abstract
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Daeseungkitang, the prescription which is composed of Rhei Radix, Magnoliae Cortex, Ponciri Fructus and Natrii Sulfas, has been used for the effect of expelling pathogenic heat and loosening the bowels, promoting the circulation of qi to purge accumulation in the bowels in Traditional Korean Medicine. This recipe is also one of the prescription to treat stroke in Kyung Hee University Oriental Medical Hospital. This study was planned to investigate the neuroprotective effect of Daeseungkitang on the global ischemia induced by 4-vessel occlusion in Wister rats. Daeseungkitang extract was lyophilized with ethanol after reflux extraction with water. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number showed significant protective effects of samples compared with control group which was administrated with normal saline in the intraperitoneal injection of 1000 ㎎/㎏ and 500 ㎎/㎏ of Daeseungkitang extracts at 0, 2 and 6 hours after inducing cerebral ischemia.
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KEYWORD
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